A recently published randomized and controlled double-blind clinical trial concluded that when participants with obesity were supplemented with 500 mg Saccharomyces boulardii twice per day at mealtimes for 60 days, they had a number of improvements related to body composition, weight loss, and insulin sensitivity compared to the group receiving placebo. In a total of 25 study participants, both groups were also asked to moderately reduce their caloric intake, though only those receiving the active treatment had a significant reduction in weight (−2.73 kg total weight, and −0.97 kg/m2 in BMI). The active group also had a significant decrease in fat mass as measured by DEXA, without any change in fat-free mass, as well as significant reductions in fasting insulin, HOMA index, weight loss, and uric acid. The group receiving the active treatment also had a significant increase in 25-OH vitamin D levels.
Although a small study, it may be the first human clinical trial of S. boulardii as a means of improving metabolic health and reducing adiposity in individuals with obesity. Animal studies have indicated that S. boulardii’s probiotic effect is likely responsible for improvements in insulin sensitivity and reduced fat mass.
FloraMyces™ is a special freeze-dried strain of non-GMO Saccharomyces boulardii isolated from Litchi fruits. Unlike other products containing this organism‚ FloraMyces™ is dairy and lactose free and does not require refrigeration. Benefits of this source may include broader bioactivity and increased protection of the digestive mucosa. Also‚ it is this strain that has been most studied for its efficiency in the prevention of antibiotic-associated diarrheas‚ and as a general supplement for optimum gastrointestinal health.